The Prague House in Brussels is a unique regional center located in the heart of the European Union's capital. The house serves as a platform for showcasing the rich cultural heritage of the Czech Republic, while also fostering dialogue and cooperation between the City of Prague and the EU.

The Prague house ranks among the most prestigious and state-protected memorials of Brussels, and rightly so. It is located in the so called European Quarter in the immediate vicinity of all of the most important European institutions, as well as a number of offices representing European regions, international associations and other institutions. The Representation of Prague to the EU has been residing in this house since June 2002.